Punjab family ravaged by Alzheimer’s banks on gene test

NEW DELHI: A curious case from Punjab has rattled not just Kuldeep Kaur and her family but even the experts who have been striving for over a year to solve her case. Kaur, a 32-year-old mother of two, was living a healthy life till September 2011 when she suddenly developed memory loss. She stopped recognizing people, forgot meals and became urinary incontinent — a pattern observed in her family including her father, grandfather, great grandmother and several other blood relatives.

Kaur had been suffering from an extremely rare disease called familial Alzheimer's that runs into families. This was declared two days ago in a genetic test conducted by a research group based in France.

"This is the first time we have come across any such patient. Her 26-year-old brother had approached us two years ago for genetic testing, fearing that he might also suffer from the same fate as his family members. We did some testing but the mutation in gene could not be identified. Finally, a research group in France offered to do the genetic testing for free and the results came in," said Dr Sunita Bijarniya Mahay, metabolic physician and geneticist at the Center of Genetic Medicine, Ganga Ram Hospital.

Now they will do predicting testing on the brother and Kuldeep's blood relatives, Dr Sunita said, to rule out or confirm the possibility of mutation of the same gene in them. "Though there is no cure for familial Alzheimer's, the tests would help them beat the angst. We can also try to manage the positive cases using best post possible medical intervention," she added.

According to Harmohan Singh, Kuldeep's brother, most of their family members could not survive beyond 50 years. "We always thought it was a family curse and would lead to the extermination of our whole generation. But the finding of the gene responsible for the deaths has given us new hope," he said. Singh was eight when his father passed away due to the same disease.

"Kuldeep's condition is also worsening each day. She has developed urinary incontinent and has become very weak. Her children have been the worst sufferers of the tragedy and no one knows what future they have. We are poor and it is really difficult for us to even think of getting the tests done on each family member," he said.

According to Dr I C Verma, director of the center of genetic medicine at Ganga Ram Hospital, India has the largest number of patients having genetic disorders because of large number of births (27 million per year), consanguineous marriages (within relations), high frequency thalessemia and sickle cell disease.

"Prenatal genetic testing, which can help in timely identification of these risk factors, is available at most centers in India. We are now trying to acquire high-end services like Microarray Analysis that can analyse the minutest change in chromosome and next generation sequencing to multiple genes for possible mutation in one go.

"These new technologies will lead to the identification of the cause of intellectual disability, muscle weakness , brain disorders and many other genetic disorders. This will also lead to the development of newer therapies," he said.

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Pictures: Civil War Shipwreck Revealed by Sonar

Photograph by Jesse Cancelmo

A fishing net, likely only decades old, drapes over machinery that once connected the Hatteras' pistons to its paddle wheels, said Delgado.

From archived documents, the NOAA archaeologist learned that Blake, the ship's commander, surrendered as his ship was sinking. "It was listing to port, [or the left]," Delgado said. The Alabama took the wounded and the rest of the crew and put them in irons.

The officers were allowed to keep their swords and wander the deck as long as they promised not to lead an uprising against the Alabama's crew, he added.

From there, the Alabama dropped off their captives in Jamaica, leaving them to make their own way back to the U.S.

Delgado wants to dig even further into the crew of the Hatteras. He'd like see if members of the public recognize any of the names on his list of crew members and can give him background on the men.

"That's why I do archaeology," he said.

(Read about other Civil War battlefields in National Geographic magazine.)

Published January 11, 2013

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Poisoned Lottery Winner's Kin Were Suspicious

Urooj Khan had just brought home his $425,000 lottery check when he unexpectedly died the following day. Now, certain members of Khan's family are speaking publicly about the mystery -- and his nephew told ABC News they knew something was not right.

"He was a healthy guy, you know?" said the nephew, Minhaj Khan. "He worked so hard. He was always going about his business and, the thing is: After he won the lottery and the next day later he passes away -- it's awkward. It raises some eyebrows."

The medical examiner initially ruled Urooj Khan, 46, an immigrant from India who owned dry-cleaning businesses in Chicago, died July 20, 2012, of natural causes. But after a family member demanded more tests, authorities in November found a lethal amount of cyanide in his blood, turning the case into a homicide investigation.

"When we found out there was cyanide in his blood after the extensive toxicology reports, we had to believe that ... somebody had to kill him," Minhaj Khan said. "It had to happen, because where can you get cyanide?"

In Photos: Biggest Lotto Jackpot Winners

Authorities could be one step closer to learning what happened to Urooj Khan. A judge Friday approved an order to exhume his body at Rosehill Cemetery in Chicago as early as Thursday to perform further tests.

Lottery Winner Murdered: Widow Questioned By Police Watch Video

Moments after the court hearing, Urooj Khan's sister, Meraj Khan, remembered her brother as the kind of person who would've shared his jackpot with anyone. Speaking at the Cook County Courthouse, she hoped the exhumation would help the investigation.

"It's very hard because I wanted my brother to rest in peace, but then we have to have justice served," she said, according to ABC News station WLS in Chicago. "So if that's what it takes for him to bring justice and peace, then that's what needs to be done."

Khan reportedly did not have a will. With the investigation moving forward, his family is waging a legal fight against his widow, Shabana Ansari, 32, over more than $1 million, including Urooj Khan's lottery winnings, as well as his business and real estate holdings.

Khan's brother filed a petition Wednesday to a judge asking Citibank to release information about Khan's assets to "ultimately ensure" that [Khan's] minor daughter from a prior marriage "receives her proper share."

Ansari may have tried to cash the jackpot check after Khan's death, according to court documents, which also showed Urooj Khan's family is questioning if the couple was ever even legally married.

Ansari, Urooj Khan's second wife, who still works at the couple's dry cleaning business, has insisted they were married legally.

She has told reporters the night before her husband died, she cooked a traditional Indian meal for him and their family, including Khan's daughter and Ansari's father. Not feeling well, Khan retired early, Ansari told the Chicago Sun-Times, falling asleep in a chair, waking up in agony, then collapsing in the middle of the night. She said she called 911.

"It has been an incredibly hard time," she told ABC News earlier this week. "We went from being the happiest the day we got the check. It was the best sleep I've had. And then the next day, everything was gone.

"I am cooperating with the investigation," Ansari told ABC News. "I want the truth to come out."

Ansari has not been named a suspect, but her attorney, Steven Kozicki, said investigators did question her for more than four hours.

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Supreme Court to decide restrictions on groups fighting HIV/AIDS

The Supreme Court will decide whether the federal government can force groups that receive funding for overseas anti-HIV and AIDS programs to adopt policies opposing prostitution and sex trafficking.

The provision is part of a 2003 law that authorized billions of dollars of spending to combat infectious diseases around the world. But the groups that do the work said the requirement would undermine their anti-AIDS efforts and is an intrusion on their free-speech rights.

The U.S. Court of Appeals for the 2nd Circuit agreed with the groups.

“Compelling speech as a condition of receiving a government benefit cannot be squared with the First Amendment,” Circuit Judge Barrington Parker wrote in a 2 to 1 decision.

“Furthermore, the targeted speech, concerning prostitution in the context of the international HIV/AIDS-prevention effort, is a subject of international debate. The right to communicate freely on such matters of public concern lies at the heart of the First Amendment.”

The case was one of six the Supreme Court accepted Friday as it begins to complete its docket for the current term.

Solicitor General Donald B. Verrilli Jr. told the court that the language in the U.S. Leadership Against HIV/AIDS, Tuberculosis and Malaria Act of 2003 is meant to ensure that its nongovernmental partners comply with a “strategy that seeks not only to treat HIV/AIDS but to reduce the behavioral risks that foster its spread.”

Congress has determined that “participating in the sex trade or sex trafficking carries serious risks for women, men and children across the globe,” Verrilli wrote.

But the groups in the coalition that brought the suit, which include Pathfinder International and InterAction, say their work in Africa and Asia could be hurt by adopting the provision.

The groups in their brief told the court that they recognize the harms associated with prostitution but also believe “adopting a policy that explicitly opposes prostitution would jeopardize [their] effectiveness in working with high-risk groups to fight HIV/AIDS.”

They added that the broadly worded restriction would “compel them to adopt and espouse as their own a certain viewpoint, and to prohibit ‘inconsistent’ speech and activities, even if undertaken with private funds outside the scope of any federally funded program.”

The case is

U.S. Agency for International Development v. Alliance for Open Society International
. Justice Elena Kagan recused herself from the case, presumably because she had worked on it during her time as President Obama’s solicitor general.

In other action, the justices said they would tackle a question that has split lower courts: whether a defendant’s silence before he is arrested and read his Miranda rights can be used against him in court.

The case comes from Texas, where Genovevo Salinas was suspected of shooting and killing Juan and Hector Garza after a party in December 1992. Police went to see Salinas after he was identified as one of the attendees and his father had turned over a shotgun.

Salinas cooperated with questioning at the police station until he was asked whether the shells found at the crime scene would match the shotgun. He did not answer and was later charged.

The first attempt to convict Salinas ended in a mistrial. At the second, over the objections of Salinas’s defense lawyer, prosecutors put considerably more emphasis on his refusal to answer the question about the shotgun shells, according to court briefs.

The prosecutor told the jury that “an innocent person” asked such a question would say no. Salinas, on the other hand “wouldn’t answer that question.” Salinas did not testify.

Salinas’s conviction was upheld by the Texas Court of Criminal Appeals. But it noted that “nearly all of the courts that have addressed this issue have noted the conspicuous split and the lack of guidance from the Supreme Court,” according to the Salinas brief.

The state of Texas said the appeals court came down on the right side of the split.

But Stanford law professor Jeffrey L. Fisher, representing Salinas, said the court should make it clear that silence is a right in all circumstances.

“When law enforcement agents question someone about his or her potential involvement in criminal activity, the individual has two choices: speak or remain silent,” Fisher wrote. “If the latter necessarily creates evidence of guilt, then the right the Constitution grants him to remain silent is little more than a trap for the unwary.”

The case is
Salinas v. Texas
.

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US study warns of extreme heat, more severe storms

WASHINGTON: A government report warned on Friday that the United States could face more frequent severe weather including heat waves and storms for decades to come as temperatures rise far beyond levels being planned for.

The draft Third National Climate Assessment, a scientific study legally mandated to advise US policymakers, made few bones that carbon emissions have been causing climate change -- a source of controversy among some lawmakers.

"Evidence for climate change abounds, from the top of the atmosphere to the depths of the oceans," the study said. "The sum total of this evidence tells an unambiguous story: The planet is warming."

The study, which was submitted for public and expert review and could be revised, said there was "strong evidence" that human activity had already roughly doubled the probability of extreme heat of the kind seen in Texas and Oklahoma in the summer of 2011.

The assessment expected temperatures to keep rising and offered different scenarios for the future -- including temperatures rising between 2.8 and 5.6 degrees Celsius (5 and 10 degrees Fahrenheit) after 2050 if emissions climb further.

Such a rise would be far beyond the level anticipated by world leaders in UN-backed climate change negotiations, which have committed to holding warming to no more than two degrees Celsius above pre-industrial levels.

The report warned that climate change "threatens human health and well-being in many ways," including through more frequent storms, wildfires, diseases and worse air quality.

Rising sea levels have already damaged infrastructure and climate change could increasingly reduce the reliability of water supplies, particularly in the southern half of the United States and Great Plains, the report said.

While US agriculture will likely remain resilient in the next 25 years, yields of major crops could start declining by mid-century and warming oceans could threaten fish, the study said.

The draft assessment said that some additional climate change was "now unavoidable" but said that the United States still could decide how much to allow.

The draft assessment was released three days after the National Oceanic and Atmospheric Administration said that 2012 was easily the warmest year on record in the continental United States and ranked second for extreme weather.

Environmental advocates hoped that the release of the draft report would bring fresh momentum to efforts to tackle climate change.

"Climate change is taking its toll on people and their economies, and will only become more intense without a strong and rapid response here in the United States and around the globe," Andrew Steer, president of the World Resources Institute, said in a statement.

President Barack Obama has hinted he will make a new effort on climate change in the wake of his November 6 re-election and massive storm Sandy, which killed at least 120 people in the US Northeast.

Efforts by Obama's Democratic Party to mandate cuts in carbon emissions failed in 2010 in the Senate. Lawmakers of the rival Republican Party said that legislation would be too costly and voiced doubt over climate science.

Since then, the Obama administration has ordered higher standards for power plants. US emissions dropped in 2011, largely due to increased use of natural gas instead of coal.

World Bank president Jim Yong Kim, who released a report in November that warned of potentially catastrophic 4.0 degree Celsius warming if no action is taken, said that evidence is "overwhelming" on climate change.

Speaking on Friday at a luncheon honouring Korean Americans, Kim voiced fear that his three-year-old son would live "a world that looks completely different from the world we have today" when he nears his father's age in 2060.

"If you have a three-year-old child, or if you have a three-year-old grandchild, what you've got to understand is, if we don't act aggressively on climate change, the world they live in will be daily fights over access to water, daily fights over access to food," he said.

- AFP/al

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Carnatic music: Classic collaborations work

CHENNAI: Shannon Donald, who lives in Mumbai, doesn't mind going for a Carnatic concert these days. And that's not because she grew up listening to south Indian classical music. "I love the singing style now," says the singer, who was amazed to see musician Bombay Jayashri being a picture of composure at MTV's Coke Studio a year ago.

"I was a backing vocalist on the episode in which she sang with Bollywood singer Richa Sharma. Though we had a long day, when it came to shooting her parts, she nailed every note effortlessly," says Donald about Jayashri, who was nominated on January 10 for the 2013 Oscars for writing a Tamil song, 'Pi's Lullaby', for Ang Lee's fantasy epic, 'Life of Pi'.

For many like Jayashri, collaborating with artists from other fields is not just about covering more creative ground. Notching up unlikely fans for classical music is one of the benefits that Jayashri and other Carnatic artists treasure while jamming with world musicians.

"After the Coke Studio episode, more people know me and come for my concerts. It's a win-win situation," says Jayashri, who has worked with Egyptian singer Hisham Abbas, done jugalbandis with Hindustani musicians Ronu Majumdar and sung for Bharatanatyam dancer Leela Samson's performances.

"I do collaborations because I like doing new things," says Jayashri. According to fellow artists like flautist S Shashank, it could have been Jayashri's love for experimentation that helped 'Life of Pi' director Ang Lee zero in on her for the Oscar-nominated project.

"I got to work on guitarist John McLaughlin's album 'Floating Point' because I work with world musicians. The album was nominated for a Grammy award in 2009," says the flautist, who will release an album, 'Here and Now', with Danish guitar maestro John Sund.

What draws western musicians is the ability of Indian musicians to improvise, says Shashank who has worked with legendary Spanish guitarist Paco de Lucia and with jazz musicians. Shashank loves the freedom to explore the flute outside the traditional concert format of Carnatic, which is a text-laden system and favours the vocalist. "It is a great learning experience. Also, as India is flooded with film music this is the only way classical musicians, especially instrumentalists, can carve a niche for themselves and establish commercially."

These artists still face the criticism that they are diluting pure music. "When, the late Pandit Ravi Shankar did jugalbandis, he was accused of doing the same. Now, jugalbandis have become the norm," says Jayashri.

To mandolin player U Shrinivas, collaborations mean more recognition for classical music. "My audience is bigger. My students come from all over the world to learn to Carnatic music," he says. And to Shrinivas, who is happy and proud of Jayashri's Oscar nomination, this could well be the best time for Indian classical music.

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Pictures: Civil War Shipwreck Revealed by Sonar

Photograph by Jesse Cancelmo

A fishing net, likely only decades old, drapes over machinery that once connected the Hatteras' pistons to its paddle wheels, said Delgado.

From archived documents, the NOAA archaeologist learned that Blake, the ship's commander, surrendered as his ship was sinking. "It was listing to port, [or the left]," Delgado said. The Alabama took the wounded and the rest of the crew and put them in irons.

The officers were allowed to keep their swords and wander the deck as long as they promised not to lead an uprising against the Alabama's crew, he added.

From there, the Alabama dropped off their captives in Jamaica, leaving them to make their own way back to the U.S.

Delgado wants to dig even further into the crew of the Hatteras. He'd like see if members of the public recognize any of the names on his list of crew members and can give him background on the men.

"That's why I do archaeology," he said.

(Read about other Civil War battlefields in National Geographic magazine.)

Published January 11, 2013

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Obama Promises Faster Transition in Afghanistan

President Obama and Afghan President Hamid Karzai said today that most U.S. combat operations in Afghanistan would end this spring, signaling a quickening troop drawdown that will bring the decade-long war to a close at the end of 2014.

"Our troops will continue to fight alongside Afghans when needed, but let me say it as plainly as I can: Starting this spring, our troops will have a different mission -- training, advising, assisting Afghan forces," Obama announced at an East Room news conference in Washington.

"It will be a historic moment and another step toward full Afghan sovereignty, something I know that President Karzai cares deeply about, as do the Afghan people," he said.

Administration officials said Afghan forces were "exceeding initial expectations" in their capabilities. Afghan security forces are expected to lead 90 percent of security operations across the country in February.

"By the end of next year -- 2014 -- the transition will be complete," Obama said. "Afghans will have full responsibility for their security, and this war will come to a responsible end."

The rosy assessments belied the serious political, economic and security challenges that remain.

Left unanswered by Obama and Karzai: How many U.S. troops might stay after 2014; what their mission would be and whether they could be effective; and whether the forces would have immunity from prosecution in Afghan courts.

Charles Dharapak/AP Photo

President Hamid Karzai Addresses Afghan Sovereignty at White House Watch Video

Afghanistan: Insider Attacks Mark War's 11th Anniversary Watch Video

Afghanistan Troop Surge Ends at Tumultuous Point Watch Video

Obama said he was still reviewing recommendations from the Pentagon and will make an announcement in the coming weeks after penning an anticipated bilateral security agreement with Afghanistan. Karzai said the exact number would be up to the United States to decide.

Both leaders confirmed in a statement that the United States "does not seek permanent bases in Afghanistan."

They also agreed today to turn over battlefield combatants held by the U.S. military in Afghanistan to Afghan government control, which has been long-sought by Karzai.

Roughly 66,000 U.S. troops are serving in Afghanistan. The military has proposed keeping several thousand troops in the country after 2014 as advisers, trainers and logistical support for Afghan forces; the White House has said it remains open to pulling out all troops entirely.

Obama's visit with Karzai was the first face-to-face encounter since the November election and since last year's dramatic increase in so-called green-on-blue attacks, when U.S. and NATO soldiers have been killed by the Afghans they are training or working alongside.

There were 45 insider attacks in 2012 that resulted in 62 deaths among coalition forces, including 35 Americans. There has been one attack already in the first 11 days of 2013.

The White House summit included a private Oval Office meeting between Obama, Karzai and Vice President Joe Biden. The trio also attended a private lunch in the Old Family Dining Room.

Karzai Thursday attended meetings with Defense Secretary Leon Panetta and top military brass at the Pentagon, where he was afforded all the pomp and circumstance accorded a head of state: a 21-gun salute, and marching bands and honor guards from the Army, Navy, Air Force, Marines and Coast Guard.

Karzai's relationship with the United States has at times been a rocky one as he has sometimes made critical statements about the allied troop presence in his country. U.S. officials believe he has made those comments out of political expediency to improve his standing with Afghans and show his independence.

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Bibles used by King, Lincoln to be part of Obama’s second inauguration

Martin Luther King Jr. carried a black leather King James Bible on his journeys as a young pastor starting out in Montgomery, Ala. He turned to this “traveling Bible” for inspiration, his family says, as he fought for freedom and equality.

President Obama will put his hand over King’s well-worn Bible at his public swearing-in at the U.S. Capitol on Jan. 21, the holiday celebrating the birthday of the slain civil rights leader. King’s Bible will be stacked with the burgundy velvet and gilded Bible used by President Abraham Lincoln at his first inauguration.

Obama chose the Lincoln Bible for his inauguration in 2009, making him the first president to do so since it was initially used in 1861. President Harry S. Truman also used two Bibles, as did Dwight D. Eisenhower and Richard M. Nixon.

The announcement about the Bibles, to be made publicly Thursday, is part of the slow unspooling of inaugural details that fascinates lovers of ceremonial Americana.

Presidential inaugurations have become more filled with rites, and such decisions are especially weighty now at a time when the White House is aware that Americans are struggling to come together.

King’s family said in a statement that he would be “deeply moved” to see Obama use the traveling Bible on Martin Luther King Jr. Day, “and we hope it can be a source of strength for the President as he begins his second term.”

“With the Inauguration less than two weeks away, we join Americans across the country in embracing this opportunity to celebrate how far we have come, honor the legacy of Martin Luther King Jr. through service, and rededicate ourselves to the work ahead,” the statement added.

According to the Presidential Inaugural Committee, which organizes the swearing-in ceremony, King traveled with various books, including this Bible. “It was used for inspiration and preparing sermons and speeches, including during Dr. King’s time as pastor of Dexter Avenue Baptist Church” in Montgomery, the committee said in a statement.

Obama and Vice President Biden will be sworn in privately on Sunday, Jan. 20 — the date required by the Constitution. For that first ceremony, Obama will use the family Bible of his wife’s family. According to the inaugural committee, that Bible “was a gift from the First Lady’s father, Fraser Robinson III, to his mother, LaVaughn Delores Robinson, on Mother’s Day in 1958. Mrs. Robinson was the first African-American woman manager of a Moody Bible Institute’s bookstore.” That Bible was the only one Michelle Obama’s grandmother used after that, a committee statement said.

For both the private and then the Monday public ceremonies, Biden will be sworn in with a Bible that has been in his family since 1893: a five-inch-thick volume with a Celtic cross on the cover. He also used it for his swearings-in as a U.S. senator and in 2009 as vice president.

Some aspects of the inaugural ceremony have changed slightly over the decades. Having official prayers offered dates only to the 1930s, historians say. But presidents have used Bibles to be sworn in since George Washington, even though the Constitution does not require it. The Constitution also does not require the phrase “So help me God” at the end, but that has become standard, said Donald Ritchie, the historian of the U.S. Senate.

He also noted that the image of the president’s spouse holding the Bible dates only to Lady Bird Johnson doing so in 1965.

Chief justices of the Supreme Court now traditionally deliver the oath, but Ritchie said any federal official can do so.

Several non-Christian members of Congress have recently used other scriptures, including Rep. Keith Ellison, the first Muslim elected to Congress, in 2007. The Minnesota Democrat used a Koran owned by Thomas Jefferson.

Obama veered from tradition in one key aspect of the ceremony: He invited Myrlie Evers-Williams, widow of slain civil rights figure Medgar Evers, to deliver the invocation prayer. It will be the first time a woman, and a layperson rather than clergy, has done so.

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US flu outbreak claims at least 18 lives

WASHINGTON: The United States was in the grip Thursday of a deadly influenza outbreak that has hit harder and earlier than in previous years, and has claimed the lives of at least 18 children.

"It looks like the worst year we had since 2003-2004," said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.

Fauci said this year's influenza strain, which has sickened thousands across the country, is particularly severe.

"The type of flu is one that generally is more serious. It's the H3N2 variety, which is historically more serious than we see with other types of virus," he said.

The epidemic, which broke out at the beginning of December, has caused some 2,200 hospitalizations across the United States, federal health officials said.

Particularly hard hit has been the northeastern city of Boston, where officials have declared a public health emergency.

City officials there said there so far have been about 700 confirmed cases of flu, almost 10 times the number from this time last year.

"This is the worst flu season we've seen since 2009, and people should take the threat of flu seriously," Boston Mayor Thomas Menino said in a statement.

"I'm urging residents to get vaccinated if they haven't already. It's the best thing you can do to protect yourself and your family. If you're sick, please stay home from work or school," he said.

Joe Bresee, chief of the Epidemiology and Prevention Branch of the Centers for Disease Control and Prevention's Influenza division, said officials don't yet know how much worse this year's outbreak will get.

"While we can't say for certain how severe this season will be, we can say that a lot of people are getting sick with influenza and we are getting reports of severe illness and hospitalizations," he said.

US states, particularly in the northeast of the country, have seen a sharp spike in emergency room visits from patients reporting flu-like symptoms, according to the federal CDC in Atlanta.

In Allentown, Pennsylvania, one hospital had to erect a large outdoor tent to admit and treat the large number of flu sufferers.

Health officials said that the flu vaccine is a good match for the strain of influenza circulating around the nation, and confers about 60 per cent to 65 per cent protection against the illness.

"You might get the flu but it will likely be less severe if you are vaccinated," Fauci said.

- AFP/ck

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